Computational approaches to metabolic engineering utilizing systems biology and synthetic biology

Computational approaches to metabolic engineering utilizing systems biology and synthetic biology

Metabolic engineering modifies cellular function to address various biochemical applications. Underlying metabolic engineering efforts are a host of tools and knowledge that are integrated to enable successful outcomes. Concurrent development of computational and experimental tools has enabled different approaches to metabolic engineering. One approach is to leverage knowledge and computational...

Synthetic biology and metabolic engineering approaches to produce biofuels.

Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived from insight into: (i) system structure and the mechanism of biological networks such as gene regulation, protein interactions, signaling, and...

Synthetic Biology: Engineering Biological Systems

On June 26, 2000, President Bill Clinton and Prime Minister Tony Blair, along with Francis Collins, director of the Human Genome Project at the NIH, and Craig Venter, president of Celera Genomics, announced the arrival of the genomic era with the sequencing of the first draft sequence of the human genome. With this wealth of information, scientists and policy-makers alike were eager to welcome ...

Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering.

Metabolic pathways can be engineered to maximize the synthesis of various products of interest. With the advent of computational systems biology, this endeavour is usually carried out through in silico theoretical studies with the aim to guide and complement further in vitro and in vivo experimental efforts. Clearly, what counts is the result in vivo, not only in terms of maximal productivity b...